Journal News

Our internal ecology

Ecosystem models help explain the diversity of the gut microbiome
Laurel Oldach
Sept. 29, 2020

According to a recent estimate, if you sample enough humans’ intestines, almost 40,000 types of microbe can be found. Any individual may have 100 trillion individual micro-organisms in one or two thousand taxonomic groups. How does the microbiome maintain such diversity?

One model to explain the enormous variety borrows from studies of larger ecosystems. A well-known theory in ecology, nonequilibrium coexistence of competitors, suggests that as an environment fluctuates, different species gain an edge over neighbors — but their ascendance rarely lasts long.

Cover-890x496.jpg
Leyuan Li
Macro- and microecosystems may have more in common than we might think.

Intestinal nutrients fluctuate as the human host eats and excretes, in time with the physiology of sleep–wake cycles, and along the length of the gut. A layer of mucus that protects host cells from commensal microbes introduces new oligosaccharides as a fuel source and also separates microbial communities into mucosal and luminal niches. As conditions change, species in the microbiome shift in abundance and jockey for survival, and the constantly changing competitive edge keeps the ecosystem diverse.

According to University of Ottawa postdoctoral fellow Leyuan Li, the time is ripe for microbiome studies to apply population modeling and systems dynamics from macroecology to this more intimate ecosystem.

“Most of the time we study the gut microbiome as a whole: We sequence one sample as if it were representative of our whole gut,” said Li. “The gut is actually a heterogeneous system … so we need to start thinking about the gut microbiome like a rainforest.”

Li, who conducted her Ph.D. studies building artificial ecosystems, now studies gut microbiome dynamics in health and diseases such as inflammatory bowel disease in the lab of Ottawa professor Daniel Figeys. In a recent review in the journal Molecular & Cellular Proteomics, the pair offer an introduction to microbiome ecology.

The review highlights the potential for metaproteomics, which characterizes the proteins of whole communities of microbes, to describe microbial function. Most microbiome studies use metagenomics, ribosomal RNA sequencing of the mixed population of a microbial community, to identify the bacteria, fungi and archaea that are present. Li thinks metaproteomics also may help researchers road-test increasingly popular ex vivo experimental models of the microbiome to make sure they match up to the real thing.

“Using metagenomics, you know who are there and what they can do,” Li said. “With metaproteomics you know who are there and what they are doing.”

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition monthly.

Learn more
Laurel Oldach

Laurel Oldach is a former science writer for the ASBMB.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Science

Science highlights or most popular articles

Melissa Moore to speak at ASBMB 2025
ASBMB Annual Meeting

Melissa Moore to speak at ASBMB 2025

April 2, 2025

Richard Silverman and Melissa Moore are the featured speakers at the ASBMB annual meeting to be held April 12-15 in Chicago.

 A new kind of stem cell is revolutionizing regenerative medicine
Feature

A new kind of stem cell is revolutionizing regenerative medicine

April 1, 2025

Induced pluripotent stem cells are paving the way for personalized treatments to diabetes, vision loss and more. However, scientists still face hurdles such as strict regulations, scalability, cell longevity and immune rejection.

Engineering the future with synthetic biology
ASBMB Annual Meeting

Engineering the future with synthetic biology

March 31, 2025

Learn about the ASBMB 2025 symposium on synthetic biology, featuring applications to better human and environmental health.

Scientists find bacterial ‘Achilles’ heel’ to combat antibiotic resistance
Webinar

Scientists find bacterial ‘Achilles’ heel’ to combat antibiotic resistance

March 28, 2025

Alejandro Vila, an ASBMB Breakthroughs speaker, discussed his work on metallo-β-lactamase enzymes and their dependence on zinc.

Host vs. pathogen and the molecular arms race
ASBMB Annual Meeting

Host vs. pathogen and the molecular arms race

March 28, 2025

Learn about the ASBMB 2025 symposium on host–pathogen interactions, to be held Sunday, April 13 at 1:50 p.m.

Richard Silverman to speak at ASBMB 2025
ASBMB Annual Meeting

Richard Silverman to speak at ASBMB 2025

March 27, 2025

Richard Silverman and Melissa Moore are the featured speakers at the ASBMB annual meeting to be held April 12-15 in Chicago.