Neurobiology

Finding a missing piece for neurodegenerative disease research

Ursula Jakob and a team at the University of Michigan have found that the molecule polyphosphate could be what scientists call the “mystery density” inside fibrils associated with Alzheimer’s, Parkinson’s and related conditions.

What I’ve learned about water, aging and protein quality control

Alice Liu thought an increase in heat shock protein chaperones would prevent misfolding in Huntington’s disease proteins. The results surprised her, and water was the key.

Helping mitochondria run smoothly may protect against Parkinson’s disease

As the powerhouse of the cell, mitochondria lie at the intersection of many essential biochemical pathways. When they go awry, neurodegenerative diseases can result.

Scientists discover brain circuits for placebo effect pain relief

A new pain control pathway from the cortex to the cerebellum is crucial when the expectation of relief leads to pain alleviation without a therapeutic intervention.

Mapping out the protein path to hearing

To determine the profile of inner hair cell proteins, a team of researchers develops a technique that optimizes proteomics for limited sample sizes.

From the journals: MCP

Beyond microscopy: Mass spec's role in biopsies. Proteomic changes in learning and memory. Mapping mitochondria using mass spec. Read about recent papers on these topics.

From the journals: MCP

Unlocking a metabolic disorder mystery. The many roles of lactate. Tools can unveil dementia biomarkers. Read about these recent papers.

Cell’s 'garbage disposal' may have another role

Researchers at Johns Hopkins University have determined that the proteasome could be helping neurons near skin sense the environment.

Decoding microglial language

Emory University scientists characterize extracellular vesicles that facilitate intercellular communication.