Disease mechanisms and treatments

Disease-linked mutations disrupt protein phase behavior

Researchers find that pathogenic missense mutations are enriched threefold in phrase-separating intrinsically disordered regions of proteins.

Novel inhibitor targets RAS-driven cancers

Researchers in Louisville identify a small-molecule drug that blocks RALGEF signaling downstream of mutant RAS. The compound suppresses tumor growth with low toxicity, revealing a new therapeutic strategy for RAS-driven malignancies.

Catching tau in the act

Using a new proximity-labeling approach, researchers reveal how tangles of the brain-associated protein tau may disrupt RNA biology long before neurons die.

Revealing the glycoproteome of a cancer subtype

Researchers mapped the glycoproteome of extrahepatic cholangiocarcinoma and compared it to intrahepatic tumors. Differences in sugar modifications and immune cell content suggest new biomarkers and guide development of targeted immunotherapies.

Heat shock proteins as a promising breast cancer therapeutic

Researchers unveiled isoform-specific targets on heat shock protein 90 which may be beneficial in therapeutic development.

Blood proteomics reveals fungal infection signatures for faster diagnosis

Whole-blood proteomics identifies more than 3,000 host and 160 fungal proteins during cryptococcal infection, offering potential biomarkers for faster diagnosis and improved monitoring without invasive spinal taps.

Glutathione pathway implicated in rare disease

Researchers found that glutathione metabolism plays a central role in the pathogenesis of rare disease methylmalonic aciduria using a novel multiomics approach.

Novel way to uncover tumor microenvironment proteomics

Researchers at the Weizmann Institute of Science developed a novel single-cell approach that facilitates the study of proteins surrounding lung cancer cells.

When oncogenes collide in brain development

Researchers at University Medical Center Hamburg, found that elevated oncoprotein levels within the Wnt pathway can disrupt the brain cell extracellular matrix, suggesting a new role for LIN28A in brain development.