Disease mechanisms and treatments

Richard Silverman to speak at ASBMB 2025
Richard Silverman and Melissa Moore are the featured speakers at the ASBMB annual meeting to be held April 12-15 in Chicago.

Pan-kinase inhibitor for head and neck cancer enters clinical trials
A drug targeting the scaffolding function of multiple related kinases halts tumor progression.

From the Journals: JLR
Promising therapeutic candidate for steatosis. Unique lipid profiles in glycogen storage disease. Microglial lactic acid mediates neuroinflammation. Read about these recent papers.

New mass spectrometry assay speeds up UTI diagnosis
Scientists in Quebec use liquid chromatography–mass spectrometry to reduce the time needed to test for bacteria in urine from days to minutes — and with smaller samples.

Unsheathing the role of myelin lipids in Alzheimer’s disease
Xianlin Han, an ASBMB Breakthroughs speaker, discussed his pioneering work on lipidomics and the role of sulfatide lipids in Alzheimer's disease.

From the JBC archives: Madness, indoles and mercury-based cathartics
A 1907 paper sought to resolve an ongoing question of whether indole, a bacterial molecule in the gut, could cause insanity if overproduced.

Becoming a scientific honey bee
At the World Science Forum, a speaker’s call for scientists to go out and “make honey” felt like the answer to a question Katy Brewer had been considering for a long time.

Biotech startup worms its way into therapeutics
Andrea Choe's company, Holoclara, has created an anti-inflammatory drug based on a molecule from worms.

Tiny laboratories that fit in your hand can rapidly identify pathogens using electricity
Pathogens have distinct electrical charges, shapes and sizes. Measuring how quickly they move through an electric field can help researchers separate different species in a sample.