Disease mechanisms and treatments

Unsheathing the role of myelin lipids in Alzheimer’s disease

Xianlin Han, an ASBMB Breakthroughs speaker, discussed his pioneering work on lipidomics and the role of sulfatide lipids in Alzheimer's disease.

From the JBC archives: Madness, indoles and mercury-based cathartics

A 1907 paper sought to resolve an ongoing question of whether indole, a bacterial molecule in the gut, could cause insanity if overproduced.

Becoming a scientific honey bee

At the World Science Forum, a speaker’s call for scientists to go out and “make honey” felt like the answer to a question Katy Brewer had been considering for a long time.

Biotech startup worms its way into therapeutics

Andrea Choe's company, Holoclara, has created an anti-inflammatory drug based on a molecule from worms.

Tiny laboratories that fit in your hand can rapidly identify pathogens using electricity

Pathogens have distinct electrical charges, shapes and sizes. Measuring how quickly they move through an electric field can help researchers separate different species in a sample.

Ubiquitination by TRIM13: An ingredient contributing to diet-induced atherosclerosis

Researchers help unravel the molecular mechanism behind plaque formation in cardiovascular disease.

Predicting fatty liver disease from a tiny blood sample

Obesity and being overweight aren't the only factors that contribute to liver disease. New tests can help identify who is at risk or already has the disease, even in people who are lean or have a normal weight.

From the journals: JLR

Fixation method to quantify brain metabolites. Belly fat and liver disease crosstalk. Stopping heart diseases in schizophrenic patients. Read about the recent JLR papers on these topics.

UCLA researchers engineer experimental drug for preventing heart failure after heart attacks

This new single-dose therapy blocks a protein that increases inflammation and shows promise in enhancing muscle repair in preclinical models.