Cancer

Gene-mutation pathway discovery paves way for targeted blood cancers therapies

A new study by researchers at the universities of Texas and Chicago explains the enzymatic activity that’s needed for tumor suppression in leukemias and other cancers.

Cholesterol synthesis and cancer

Researchers find that the active form of a key cholesterol synthesis enzyme is upregulated in endometrial cancer tissues.

From the journals: JBC

Lung cancer cells resist ferroptosis. ORMDL3 in ulcerative colitis. Novel genetic variants in thyroid cancer. Read about these recent papers.

Radioactive drugs strike cancer with precision

The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects.

Scientists track 'doubling' in origin of cancer cells

Researchers at Johns Hopkins say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times.

From the journals: JLR

Switching cancer cells from pro- to antitumor. Species-specific skeletal muscle metabolism. Protein deletion improves metabolic disorders Read about recent papers on these topics.

'Protein sandwich' could transform cancer drug discovery

A team led by Alessio Ciulli has defined a new class of so-called “intramolecular bivalent glue,” which binds proteins that would otherwise stay apart.

From the journals: MCP

Amino acids and sulfate signatures. Unveiling phosphatase substrates. Simplifying bacterial proteome profiling. Read about recent papers on these topics.

Focusing on a pivotal axis in chemoresistance

Answers may lie in microRNA changes at the intersection of a cell cycle–regulating protein and a transcription factor that plays various roles in cancer.