Cancer
Elucidating how chemotherapy induces neurotoxicity
Andre Nussenzweig will receive the Bert and Natalie Vallee Award at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.
From receptor research to cancer drug development: The impact of RTKs
Joseph Schlessinger will receive the ASBMB Herbert Tabor Research Award at the 2025 ASBMB Annual meeting, April 12–15 in Chicago.
Gene-mutation pathway discovery paves way for targeted blood cancers therapies
A new study by researchers at the universities of Texas and Chicago explains the enzymatic activity that’s needed for tumor suppression in leukemias and other cancers.
Cholesterol synthesis and cancer
Researchers find that the active form of a key cholesterol synthesis enzyme is upregulated in endometrial cancer tissues.
From the journals: JBC
Lung cancer cells resist ferroptosis. ORMDL3 in ulcerative colitis. Novel genetic variants in thyroid cancer. Read about these recent papers.
Radioactive drugs strike cancer with precision
The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects.
Scientists track 'doubling' in origin of cancer cells
Researchers at Johns Hopkins say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times.
From the journals: JLR
Switching cancer cells from pro- to antitumor. Species-specific skeletal muscle metabolism. Protein deletion improves metabolic disorders Read about recent papers on these topics.
'Protein sandwich' could transform cancer drug discovery
A team led by Alessio Ciulli has defined a new class of so-called “intramolecular bivalent glue,” which binds proteins that would otherwise stay apart.