Proteins and proteomics
Defeating deletions and duplications
Promising therapeutics for chromosome 15 rare neurodevelopmental disorders, including Angelman syndrome, Dup15q syndrome and Prader–Willi syndrome.
Using 'nature’s mistakes' as a window into Lafora disease
After years of heartbreak, Lafora disease families are fueling glycogen storage research breakthroughs, helping develop therapies that may treat not only Lafora but other related neurological disorders.
Cracking cancer’s code through functional connections
A machine learning–derived protein cofunction network is transforming how scientists understand and uncover relationships between proteins in cancer.
Bacterial enzyme catalyzes body odor compound formation
Researchers identify a skin-resident Staphylococcus hominis dipeptidase involved in creating sulfur-containing secretions. Read more about this recent Journal of Biological Chemistry paper.
Pesticide disrupts neuronal potentiation
New research reveals how deltamethrin may disrupt brain development by altering the protein cargo of brain-derived extracellular vesicles. Read more about this recent Molecular & Cellular Proteomics article.
A look into the rice glycoproteome
Researchers mapped posttranslational modifications in Oryza sativa, revealing hundreds of alterations tied to key plant processes. Read more about this recent Molecular & Cellular Proteomics paper.
Proteomic variation in heart tissues
By tracking protein changes in stem cell–derived heart cells, researchers from Cedars-Sinai uncovered surprising diversity — including a potential new cell type — that could reshape how we study and treat heart disease.
Parsing plant pigment pathways
Erich Grotewold of Michigan State University, an ASBMB Breakthroughs speaker, discusses his work on the genetic regulation of flavonoid biosynthesis.
Calcium channel linked to cancer drug resistance
Researchers discover a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target. Read more about this recent Journal of Biological Chemistry paper.