Proteins and proteomics

A proteomic hunt for phosphosites in the aging brain

In older mice, researchers found more enzymes that phosphorylate other proteins and changes in phosphorylation levels in proteins associated with neurodegeneration.

From the journals: JBC

Histone demethylase inhibited by own sequence. MicroRNA reduces cell cycle–related apoptosis. Multipurpose antibiotic takes on staph infections. Read about recent JBC papers on these topics.

When ribosomes go rogue

 Unusual variations in the cellular protein factory can skew development, help cancer spread and more. But ribosome variety may also play biological roles, scientists say.

Of yeasts and men: One-hour proteomes, 10 years apart

To profile the human proteome within an hour, the researchers used a new mass spectrometer and packed their liquid chromatography columns with very high pressure.

Does a protein hold the key to Alzheimer’s?

Researchers in Maryland and Massachusetts team up to study how SORL1 promotes tau trafficking and seeding in cells that leads to the neurodegenerative disorder.

MSU researchers leverage cryo-EM for decades-in-the-making breakthrough

Lee Kroos and Ben Orlando have reported the first high-resolution experimentally determined structures of the intramembrane protease SpolVFB.

What seems dead may not be dead

Vincent Tagliabracci will receive the Earl and Thressa Stadtman Distinguished Scientist Award at the ASBMB Annual Meeting, April 12–15 in Chicago.

Modified pea proteins are shaping the future of meat alternatives

University of Minnesota scientists use enzymes to mimic beef texture in plant-based protein.

Nobel for ‘breakthrough in biochemistry’

David Baker, Demis Hassabis and John M. Jumper received the chemistry prize for computational protein design and structure prediction.