Annual Meeting

A research journey spanning three countries

Meet a JBC Herbert Tabor Early Career Investigator Award winner
Nivedita Uday Hegdekar
March 18, 2022

Studying and working in a foreign country can be an enriching experience. No one understands this better than Rahul Kumar, who has studied in not one but three countries.

Kumar grew up in his native state of West Bengal, India. From a young age, he said, he was interested in understanding the whys behind disease pathologies. This inspired him to pursue a dual bachelor’s–master’s degree at the prestigious Indian Institutes of Science Education and Research, known as IISER, in Kolkata. There, he majored in biological sciences with a chemistry minor.

Rahul Kumar
Rahul Kumar

“I greatly appreciated how IISER helped me build foundational scientistic knowledge and critical thinking,” Kumar said, "particularly the vibrant lab environment of Dr. Jayasri Das Sarma, where I did my master's thesis."

While he enjoyed scientific learning, Kumar was unsure whether pursuing a Ph.D. would be the right career step. A three-month research internship at the University of Southern California proved to be the turning point. In Jennie Chen’s lab, he studied the biosynthesis and cell biology of the protein rhodopsin.

“Dr. Chen gave me the freedom to explore and think creatively,” he said. “I got to design experiments to answer different research questions. It was a life-changing experience.”

Kumar then joined Peter McPherson’s lab at McGill University in Quebec, Canada, as a Ph.D. student. His doctoral work focused on studying the DENN domain containing proteins. Many of the mutations in these proteins cause neurodevelopmental disorders.

"A part of my studies was carried out on induced pluripotent stem cells derived from patient samples," Kumar said. “This was particularly exciting, as such findings will have clinical relevance for disease treatment.”

Kumar has collaborated on other projects, one of which earned him a Journal of Biological Chemistry Tabor award. He is on track to defend his Ph.D. next fall and plans to pursue postdoctoral research.

“I have learned so much in my current lab,” he said. “As a result, I feel prepared to step out of my comfort zone and explore newer avenues in cell biology.”

Outside the lab, Kumar enjoys participating in teaching opportunities at high schools and hiking with his friends. He has thoroughly enjoyed the experience of living abroad and hopes his next research stint will give him a new location to explore.

The pandemic presents a research opportunity

The COVID-19 pandemic presented an unexpected collaborative opportunity for Rahul Kumar and a fellow graduate student, Arbim Bayati. Together they investigated the molecular process by which SARS-CoV-2, the causative virus of COVID-19, gains access into cells.

Kumar produced the purified SARS-CoV-2 spike protein (the part responsible for the infectivity of the virus) that Bayati used to determine uptake of this protein by the cell. Simultaneously, Kumar performed infectivity experiments in cells using a SARS-CoV-2 pseudovirus (a harmless, nonreplicating virus in which the surface protein is replaced with the SARS-CoV-2 spike protein).

The researchers found that after engaging with the plasma membrane, SARS-CoV-2 undergoes a molecular process called clathrin-mediated endocytosis to enter the cell. Furthermore, Kumar demonstrated that when clathrin protein was removed, the infectivity of SARS-CoV-2 drastically reduced.

This work uncovered the mechanism by which SARS-CoV-2 enters a cell and demonstrates the importance of this process in viral infectivity. The findings were published in the Journal of Biological Chemistry.

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
Nivedita Uday Hegdekar

Nivedita Uday Hegdekar is a recent Ph.D. graduate in biochemistry and molecular biology from the University of Maryland, Baltimore.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Transforming learning through innovation and collaboration
Award

Transforming learning through innovation and collaboration

Nov. 22, 2024

Neena Grover will receive the William C. Rose Award for Exemplary Contributions to Education at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.

Guiding grocery carts to shape healthy habits
Award

Guiding grocery carts to shape healthy habits

Nov. 21, 2024

Robert “Nate” Helsley will receive the Walter A. Shaw Young Investigator in Lipid Research Award at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.

Leading the charge for gender equity
Award

Leading the charge for gender equity

Nov. 19, 2024

Nicole Woitowich will receive the ASBMB Emerging Leadership Award at the 2025 ASBMB Annual meeting, April 12–15 in Chicago.

Honors for de la Fuente, Mittag and De La Cruz
Member News

Honors for de la Fuente, Mittag and De La Cruz

Nov. 18, 2024

César de la Fuente receives the American Society of Microbiology’s Award for Early Career Basic Research. Tanja Mittag and Enrique M. De La Cruz are named fellows by the Biophysical Society.

In memoriam: Horst Schulz
In Memoriam

In memoriam: Horst Schulz

Nov. 18, 2024

He was a professor emeritus at City College of New York and at the CUNY Graduate Center in Manhattan whose work concentrated on increasing our understanding of mitochondrial fatty acid metabolism and an ASBMB member since 1971.

Computational and biophysical approaches to disordered proteins
Award

Computational and biophysical approaches to disordered proteins

Nov. 14, 2024

Rohit Pappu will receive the 2025 DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, April 12-15 in Chicago.