In Memoriam

In memoriam: Tadashi Inagami

Christi Thomas
By Christi Thomas
Sept. 25, 2023

Tadashi Inagami, an emeritus biochemistry professor at Vanderbilt University known for his pioneering research contributions to hypertension, heart failure, and vascular disease, died on March 13 in Pittsburgh. He was 92. 

Tadashi Inagami

Born in Kobe, Japan, on Feb. 20, 1931, Inagami earned a bachelor’s degree in nutritional chemistry from Kyoto University in 1953. In 1958, he earned a Ph.D. in biophysical chemistry from Yale University through the Fulbright Foreign Student Program. He earned a second doctoral degree from Kyoto University in 1963.  

In 1966, Inagami became an assistant professor in biochemistry at Vanderbilt University School of Medicine, where he developed a reputation for being helpful, generous with his time, polite, gentle, and humble. He remained at Vanderbilt until his retirement in 2014. 

Inagami was the first researcher to purify mouse renin and obtain its primary structure. He identified and cloned the angiotensin II type 1 receptor and angiotensin type 2 receptor, deepening understanding of angiotensin II signal transduction and its role in cardiovascular health. He also characterized the primary structure of the rat atrial natriuretic peptide hormone, which upregulates salt excretion and lowers blood volume resulting in low blood pressure. He discovered that the angiotensin II signaling pathway leads to high cell proliferation in the heart, kidney, and blood vessel walls. These findings contributed to creation of medication to lower hypertension, such as angiotensin II type 1 receptor blockers, and treatments for heart failure and vascular and kidney disease. 

For 17 years, Inagami served as director of the interdisciplinary Specialized Center of Research in Hypertension at Vanderbilt. He published more than 500 scientific articles and mentored more than 100 graduate students and postdoctoral fellows. His many accolades included the American Heart Association/American Stroke Association Distinguished Scientist Award, the CIBA Award for Hypertension Research, and the Japan Academy Prize. Vanderbilt honored him with the Earl Sutherland Prize for Achievement in Research in 1990. 

After his retirement, Inagami and his wife, Masako, moved to Pittsburgh, where he loved attending his grandchildren’s baseball games and dance and violin recitals, and he enjoyed strolling through Squirrel Hill and Frick Park and exploring Japanese restaurants.

He is survived by his wife, Masako Inagami; daughters, Sanae Inagami and Mari Inagami; son-in-law, Ananth Krishnamurthy; and five grandchildren.

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
Christi Thomas
Christi Thomas

Christi Thomas holds a B.S. in biochemistry with a minor in biology from California State University Northridge. She is a volunteer writer for ASBMB Today.
 

Related articles

In memoriam: Henry Bourne
ASBMB Today Staff
In memoriam: Bengt Samuelsson
Christopher Radka
In memoriam: Roger Thibert
Christopher Radka
In memoriam: Thomas Devlin
Elisabeth Adkins Marnik

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Guiding grocery carts to shape healthy habits
Award

Guiding grocery carts to shape healthy habits

Nov. 21, 2024

Robert “Nate” Helsley will receive the Walter A. Shaw Young Investigator in Lipid Research Award at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.

Leading the charge for gender equity
Award

Leading the charge for gender equity

Nov. 19, 2024

Nicole Woitowich will receive the ASBMB Emerging Leadership Award at the 2025 ASBMB Annual meeting, April 12–15 in Chicago.

Honors for de la Fuente, Mittag and De La Cruz
Member News

Honors for de la Fuente, Mittag and De La Cruz

Nov. 18, 2024

César de la Fuente receives the American Society of Microbiology’s Award for Early Career Basic Research. Tanja Mittag and Enrique M. De La Cruz are named fellows by the Biophysical Society.

In memoriam: Horst Schulz
In Memoriam

In memoriam: Horst Schulz

Nov. 18, 2024

He was a professor emeritus at City College of New York and at the CUNY Graduate Center in Manhattan whose work concentrated on increasing our understanding of mitochondrial fatty acid metabolism and an ASBMB member since 1971.

Computational and biophysical approaches to disordered proteins
Award

Computational and biophysical approaches to disordered proteins

Nov. 14, 2024

Rohit Pappu will receive the 2025 DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, April 12-15 in Chicago.

Join the pioneers of ferroptosis at cell death conference
In-person Conference

Join the pioneers of ferroptosis at cell death conference

Nov. 13, 2024

Meet Brent Stockwell, Xuejun Jiang and Jin Ye — the co-chairs of the ASBMB’s 2025 meeting on metabolic cross talk and biochemical homeostasis research.