Award

Boothroyd honored for Toxoplasma gondii research

He has won the Alice and C.C. Wang Award in Molecular Parasitology
Anna Tancredi
Dec. 24, 2021

In his lab’s early years, John Boothroyd worked with both the protozoan that causes African sleeping sickness, Trypanosoma brucei, and the parasite that causes toxoplasmosis, Toxoplasma gondii. His team was one of the first to report mRNA trans-splicing and polycistronic transcription in eukaryotes from their trypanosome research. But about a decade later, Boothroyd started to feel that the trypanosome research field was becoming saturated; he wanted to go back to his early interest in intracellular biochemistry, so he focused his research on the less-explored Toxoplasma. Since then, his lab has made great strides in understanding host–parasite interactions.

John Boothroyd

Boothroyd has won the American Society for Biochemistry and Molecular Biology’s 2022 Alice and C.C. Wang Award for his seminal contributions to molecular parasitology both in the laboratory and in the greater community.

After earning his Ph.D. at the University of Edinburgh in 1979, Boothroyd was a scientist at the Wellcome Research Laboratories in the United Kingdom for three years before moving to Stanford University, where he’s worked for almost four decades. He is now a professor of microbiology and immunology and associate vice-provost for graduate education and postdoctoral affairs.

On top of his research contributions, Boothroyd aims to better the lives of students and faculty by altering how we view mentorship in the sciences. “One of my passions is to change the academic culture to recognize that mentoring is a really important and really hard job, and that people can benefit from receiving explicit training,” he said.

Elected to the National Academy of Sciences in 2016, Boothroyd continues his work to create a supportive, inclusive scientific community at a national level.

In his own lab, Boothroyd has a team-oriented approach, saying, “I strongly feel that awards like this are to the team, not me.”

In this strain, virulence varies greatly

Toxoplasma gondii has a diverse range of hosts; it can infect nearly any warm-blooded animal, including humans. An estimated 40 million people in the United States are infected with the parasite. Though many cases are asymptomatic, severe toxoplasmosis can be fatal for pregnant individuals or those with weakened immune systems, so it is crucial to understand how these parasites work. John Boothroyd and his team at Stanford want to understand what makes some strains of Toxoplasma so virulent and how the host immune system and the parasite interact.

In their most recent publication, the team used single-cell transcriptomic analysis to examine how host cell gene expression changes upon infection by Toxoplasma gondii. They compared the transcription of Toxoplasma-infected cells with cells that were injected but not invaded by Toxoplasma. While previous studies only had assessed gene expression days after infection, Boothroyd’s team measured transcription within one to three hours. They found that transcription of host immune and cellular stress response genes increases upon injection of rhoptry effector proteins. Exactly how these effectors are introduced into the host cell is one of the lab’s current focuses.

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
Anna Tancredi

Anna Tancredi received a bachelor's degree in molecular biology from Kenyon College.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Ali, Falade, Usman selected for mentoring program
Member News

Ali, Falade, Usman selected for mentoring program

Jan. 13, 2025

Bashir Ali, Omolara Falade and Olalekan Usman have been selected to participate in the Scientist Mentoring & Diversity Program for Biotechnology, which pairs ethnically diverse students and early career researchers with industry mentors.

How military forensic scientists use DNA to solve mysteries
Jobs

How military forensic scientists use DNA to solve mysteries

Jan. 10, 2025

Learn how two analysts at the Armed Forces DNA Identification Laboratory use molecular biology and genetics to identify the remains of fallen troops.

A decade of teaching the Art of Science Communication
Feature

A decade of teaching the Art of Science Communication

Jan. 7, 2025

Why now, more than ever, scientists must be able to explain what they do to non-scientists.

Of genes, chromosomes and oratorios
Profile

Of genes, chromosomes and oratorios

Jan. 1, 2025

Jenny Graves has spent her life mapping genes and comparing genomes. Now she’s created a musical opus about evolution of life on this planet — bringing the same drive and experimentalism she brought to the study of marsupial chromosomes.

In memoriam: Margaret Fonda
In Memoriam

In memoriam: Margaret Fonda

Dec. 30, 2024

She taught biochemistry in a male-dominated department at a medical school and was an ASBMB member for more than 50 years.

Sung honored for research; Sliger, Young named astronaut scholars
Member News

Sung honored for research; Sliger, Young named astronaut scholars

Dec. 23, 2024

Patrick Sung receives the 2024 Basser Global Prize from the Basser Center for BRCA at Penn Medicine. A foundation created by Mercury 7 astronauts awards scholarships to Shelby Sliger and Tara Young.