Award

Fierke works as a catalyst for change

She won the ASBMB's 2020/2021 Mildred Cohn Award in Biological Chemistry
Kerri Beth  Boggs
Nov. 1, 2019

When she was a professor at the University of Michigan, Carol Fierke helped draft a proposal to increase diversity in the chemistry department. With funding from the National Science Foundation Michigan ADVANCE program, Fierke and her colleagues developed strategies to make the department more welcoming for women and minorities.

Carol Fierke
Carol Fierke

Building her knowledge of social science literature was crucial to modifying the culture, Fierke said. She worked with a universitywide committee to develop a workshop to teach faculty about the literature and to train search committees on best practices. The Michigan chemistry department faculty went from a low of 8% to now almost 30% women.

“We completely changed the face of the department,” she said.

Now provost and executive vice president of Texas A&M University, Fierke is a distinguished enzymologist who continues her work on behalf of underrepresented groups. Scientists like Mildred Cohn, the first woman to hold the presidency of the American Society for Biochemistry and Molecular Biology, opened doors for women in the sciences and inspired her to follow their example, Fierke said, so it is fitting that she will receive the ASBMB’s 2020/2021 Mildred Cohn Award in Biological Chemistry.

Fierke’s experience as an advocate for diversity influences the way she mentors her students, particularly women and underrepresented minorities, who often struggle with building confidence.

“I tell my students you don’t have to be confident, just act confidently — eventually you become confident because people see you that way,” she said.

She encourages her students to learn skills beyond the bench and do some soul searching to find careers in which they can thrive.

“I know that when I was a doctoral student, I thought there was one career pathway, but that’s not true,” she said. “There are lots of pathways to get to a final goal.”

Fierke’s advocacy continues at Texas A&M, where she aims to increase faculty diversity, enhance interdisciplinary research and increase student success.  

Analyzing protein deacetylase mechanisms

Biological catalysts have unique active sites that determine the specificity and efficiency of substrate binding. Carol Fierke’s research has focused on understanding how metal ions in the enzyme active site can regulate catalytic mechanisms. Her award lecture during the ASBMB 2020 annual meeting will highlight her work on a group of enzymes known as protein deacetylases.

Deacetylase enzymes are involved in removing specific post-translational modifications from proteins. Fierke uses her expertise in catalysis and metal homeostasis to answer questions about which metal ions are physiologically important for the function of the enzymes. Additionally, she has made strides in understanding how metal ion switching may regulate biological function. Her lab is developing a toolbox of methods to identify the pathways and substrates utilized by these deacetylases.

The Food and Drug Administration has approved several histone deacetylase inhibitors as anticancer compounds, but the inhibitors often have serious side effects. Findings by Fierke and others may contribute to the development of new histone deacetylase inhibitors with reduced side effects and enhanced efficacy as therapeutic agents.

 

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Kerri Beth  Boggs

Kerri Beth Boggs is a graduate student in the biochemistry department at the University of Kentucky.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Gary Felsenfeld (1929–2024)
Retrospective

Gary Felsenfeld (1929–2024)

July 15, 2024

Three colleagues remember a researcher whose work at the NIH revealed the dynamic nature of chromatin and its role in gene expression and epigenetic regulation.

Getting to the genetic basis of cardiovascular disease
Journal News

Getting to the genetic basis of cardiovascular disease

July 11, 2024

Edwin G. Peña Martínez received a JBC Tabor award for associating the condition with mutations in noncoding sequences.

Protein Society announces awards
Member News

Protein Society announces awards

July 8, 2024

ASBMB members Neil Kelleher, Alexandra Newton, David Craik, David Cortez and Jeffery W. Kelly are among the honorees.

In memoriam: Herbert Cheung
In Memoriam

In memoriam: Herbert Cheung

July 8, 2024

He was a biochemist who specialized in the use of fluorescence technology and had been a member of the ASBMB since 1972.

Inspired by science — and passing it on
Research Spotlight

Inspired by science — and passing it on

July 3, 2024

Adriana Norris started a YouTube channel to take some of the mystery out of academia.

'Simple things can go wrong and cause disease'
Award

'Simple things can go wrong and cause disease'

July 2, 2024

Cancer biologist Jenny Hogstrom received a JBC Tabor award for her use of organoids to study drug resistance in cancer.