Member News

Young wins Nobel Prize
in medicine or physiology

John Arnst
Nov. 1, 2017

Michael W. Young at the Rockefeller University and Michael Rosbash and Jeffrey C. Hall at Brandeis University have won the 2017 Nobel Prize in Physiology or Medicine for their discoveries of molecular mechanisms controlling circadian rhythm.

The oscillations of the circadian rhythm are responsible for the regular, daily functioning of countless biological processes, including sleep, metabolism, hormone regulation and body temperature. By exploring the process in fruit flies, the Nobel laureates isolated the gene that drives the oscillations by encoding a protein that accumulates in cells during the day and is degraded at night. This daily cycle, by which cellular clockwork is coupled to the Earth’s, has since been observed in plants, animals, fungi and cyanobacteria.

Michael W. Young

The Nobel Assembly at Karolinska Institutet in Sweden, which issues the prize, in a press release noted that “the seminal discoveries by Hall, Rosbash and Young have revealed a crucial physiological mechanism explaining circadian adaptation, with important implications for human health and disease.”

Young, a member of the American Society for Biochemistry and Molecular Biology and the National Academy of Sciences, earned his B.A. in biology in 1971 and his Ph.D. in genetics in 1975 at the University of Texas at Austin. He followed that up with a postdoc at Stanford University. He has been a faculty member at Rockefeller since 1978.

Young will share one-third of the $1.1 million prize with Rosbash and Hall.

“In 1930, George and Ira Gershwin published their famous jazz song, ‘I Got Rhythm.’ Well, it turns out, we all got rhythm. Even the simple fruit fly got rhythm. And, amazingly, it’s the same rhythm,” says Gregory A. Petsko, an endowed professor at Weill Cornell Medical College and professor emeritus at Brandeis.

Petsko continued: “(Circadian rhythm) explains why we sleep when we do and why we feel wiped out when we take a long airplane trip across many time zones. It is one of the most fundamental processes in all higher organisms. (T)hanks to the laureates, we now know the words and lyrics — i.e, the mechanism — of that rhythm as well as we do that of the Gershwins.”

 

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
John Arnst

John Arnst was a science writer for ASBMB Today.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Sung honored for research; Sliger, Young named astronaut scholars
Member News

Sung honored for research; Sliger, Young named astronaut scholars

Dec. 23, 2024

Patrick Sung receives the 2024 Basser Global Prize from the Basser Center for BRCA at Penn Medicine. A foundation created by Mercury 7 astronauts awards scholarships to Shelby Sliger and Tara Young.

‘Our work is about science transforming people’s lives’
Interview

‘Our work is about science transforming people’s lives’

Dec. 17, 2024

Ann West, chair of the ASBMB Public Affairs Advisory Committee, sits down Monica Bertagnolli, director of the National Institutes of Health.

Pernas named fellow; Heitman and Wu elected to NAM
Member News

Pernas named fellow; Heitman and Wu elected to NAM

Dec. 16, 2024

Lena Pernas is named a fellow by the David and Lucile Packard Foundation. Joseph Heitman and Hao Wu are inducted into the National Academy of Medicine.

Awards for Maquat and Gohil; Sobrado named biochem chair
Member News

Awards for Maquat and Gohil; Sobrado named biochem chair

Dec. 9, 2024

Vishal Gohil is honored for work with copper. Lynn Maquat receives two awards for RNA research. Pablo Sobrado is named endowed chair of biochemistry.

What seems dead may not be dead
Award

What seems dead may not be dead

Dec. 4, 2024

Vincent Tagliabracci will receive the Earl and Thressa Stadtman Distinguished Scientist Award at the ASBMB Annual Meeting, April 12–15 in Chicago.

'You can't afford to be 15 years behind the parasite'
Award

'You can't afford to be 15 years behind the parasite'

Dec. 3, 2024

David Fidock will receive the Alice and C.C. Wang Award in Molecular Parasitology at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.