Member News

Young wins Nobel Prize
in medicine or physiology

John Arnst
Nov. 1, 2017

Michael W. Young at the Rockefeller University and Michael Rosbash and Jeffrey C. Hall at Brandeis University have won the 2017 Nobel Prize in Physiology or Medicine for their discoveries of molecular mechanisms controlling circadian rhythm.

The oscillations of the circadian rhythm are responsible for the regular, daily functioning of countless biological processes, including sleep, metabolism, hormone regulation and body temperature. By exploring the process in fruit flies, the Nobel laureates isolated the gene that drives the oscillations by encoding a protein that accumulates in cells during the day and is degraded at night. This daily cycle, by which cellular clockwork is coupled to the Earth’s, has since been observed in plants, animals, fungi and cyanobacteria.

Michael W. Young

The Nobel Assembly at Karolinska Institutet in Sweden, which issues the prize, in a press release noted that “the seminal discoveries by Hall, Rosbash and Young have revealed a crucial physiological mechanism explaining circadian adaptation, with important implications for human health and disease.”

Young, a member of the American Society for Biochemistry and Molecular Biology and the National Academy of Sciences, earned his B.A. in biology in 1971 and his Ph.D. in genetics in 1975 at the University of Texas at Austin. He followed that up with a postdoc at Stanford University. He has been a faculty member at Rockefeller since 1978.

Young will share one-third of the $1.1 million prize with Rosbash and Hall.

“In 1930, George and Ira Gershwin published their famous jazz song, ‘I Got Rhythm.’ Well, it turns out, we all got rhythm. Even the simple fruit fly got rhythm. And, amazingly, it’s the same rhythm,” says Gregory A. Petsko, an endowed professor at Weill Cornell Medical College and professor emeritus at Brandeis.

Petsko continued: “(Circadian rhythm) explains why we sleep when we do and why we feel wiped out when we take a long airplane trip across many time zones. It is one of the most fundamental processes in all higher organisms. (T)hanks to the laureates, we now know the words and lyrics — i.e, the mechanism — of that rhythm as well as we do that of the Gershwins.”

 

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
John Arnst

John Arnst was a science writer for ASBMB Today.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Brain-on-a-chip tech powers neuroscience research
Profile

Brain-on-a-chip tech powers neuroscience research

Nov. 4, 2024

MOSAIC scholar Brian O'Grady has engineered a biomimetic model of the brain’s blood vessels to help tackle glioblastoma.

Being a whole person outside of work
Hobbies

Being a whole person outside of work

Nov. 1, 2024

Creating art, community service, physical exercise, theater and music — four scientists talk about the activities that bring them joy.

‘We’re thankful for our reviewers’
Journal News

‘We’re thankful for our reviewers’

Oct. 31, 2024

Meet some of the scientists who review manuscripts for the Journal of Biological Chemistry, Journal of Lipid Research and Molecular & Cellular Proteomics.

In memoriam: Bruce Ames
In Memoriam

In memoriam: Bruce Ames

Oct. 28, 2024

He invented a cheap and easy way to assess mutagenicity that helped identify many environmental and industrial carcinogens; it became known as the Ames test.

Honors for DebBurman, Margaryan and Santiago–Frangos
Member News

Honors for DebBurman, Margaryan and Santiago–Frangos

Oct. 28, 2024

The Council on Undergraduate Research honors Shubhik DebBurman with a mentoring award. Anush Margaryan wins a Projects for Peace grant to teach refugees in Armenia. UPenn names Andrew Santiago–Frangos an endowed assistant professor.

In memoriam: William L. Smith
In Memoriam

In memoriam: William L. Smith

Oct. 21, 2024

He served as associate editor of both the Journal of Biological Chemistry and the Journal of Lipid Research and was an ASBMB member for more than 40 years.