Award

Postdoc wins Tabor award
for lipid membrane research

Dawn Hayward
Jan. 1, 2018

Lipid membranes surround and protect each of our cells. They serve as a first line of defense, allow for intracellular signaling and keep subcellular compartments separate. The lipid composition must therefore be diverse and distinctive enough to keep a cell running smoothly. Figuring out which lipids are needed where and when can be challenging, however. Itay Budin, a postdoctoral fellow at the University of California, Berkeley, studies lipid properties and why certain ones belong in specific cell membranes. For his research, Budin received a 2017 Journal of Biological Chemistry/Herbert Tabor Young Investigator Award.

Itay Budin is a Miller Institute junior fellow at the University of California, Berkeley, and works at the Joint BioEnergy Institute. courtesy of Itay Budin

Budin investigates how lipid composition affects membrane properties and the consequences of altering particular lipids in model organisms. Lipids make up cellular and subcellular membranes and help maintain integrity and compartmentalization. However, manipulation of these lipids to understand their roles has been done primarily in vitro, and tools to recapitulate findings within living organisms are difficult to develop. Budin uses metabolic engineering to explore lipid composition and functionality. He explained that he does this by altering the genes that give rise to particular lipids. He is then able to “rewire” these pathways within the organism to understand which lipids are necessary for a particular membrane and why. Budin and colleagues have learned that a cell’s membrane can act as an environmental sensor, and a particular set of proteins then responds to maintain homeostasis. This work was published in May 2017 in the journal Metabolic Engineering.

JBC Associate Editor Dennis Voelker presented the award to Budin in August at the 2017 Gordon Research Conference on Molecular and Cell Biology of Lipids. Receiving the award was a “great honor and real thrill,” Budin said, and receiving it from Voelker, a lipid biologist, reinforced the importance of his work. The award committee thought Budin’s work was instrumental in “assigning a crucial mechanistic role for unsaturated lipids in serving as molecular signals that liberate transcription factors from the endoplasmic reticulum in response to a variety of stimuli,” they wrote with input from Voelker.

Budin earned his Ph.D. in biochemistry and physical biology from Harvard University in the laboratory of Jack W. Szostak investigating the changes in lipid composition throughout evolution. He then came to the University of California, Berkeley, on a Miller Institute Junior Fellowship. He works with Jay Keasling at the Joint BioEnergy Institute, a research center in Berkeley focused on synthetic biology and metabolic engineering.

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
Dawn Hayward

Dawn Hayward earned a Ph.D. in biochemistry from the Johns Hopkins University School of Medicine

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Brain-on-a-chip tech powers neuroscience research
Profile

Brain-on-a-chip tech powers neuroscience research

Nov. 4, 2024

MOSAIC scholar Brian O'Grady has engineered a biomimetic model of the brain’s blood vessels to help tackle glioblastoma.

Being a whole person outside of work
Hobbies

Being a whole person outside of work

Nov. 1, 2024

Creating art, community service, physical exercise, theater and music — four scientists talk about the activities that bring them joy.

‘We’re thankful for our reviewers’
Journal News

‘We’re thankful for our reviewers’

Oct. 31, 2024

Meet some of the scientists who review manuscripts for the Journal of Biological Chemistry, Journal of Lipid Research and Molecular & Cellular Proteomics.

In memoriam: Bruce Ames
In Memoriam

In memoriam: Bruce Ames

Oct. 28, 2024

He invented a cheap and easy way to assess mutagenicity that helped identify many environmental and industrial carcinogens; it became known as the Ames test.

Honors for DebBurman, Margaryan and Santiago–Frangos
Member News

Honors for DebBurman, Margaryan and Santiago–Frangos

Oct. 28, 2024

The Council on Undergraduate Research honors Shubhik DebBurman with a mentoring award. Anush Margaryan wins a Projects for Peace grant to teach refugees in Armenia. UPenn names Andrew Santiago–Frangos an endowed assistant professor.

In memoriam: William L. Smith
In Memoriam

In memoriam: William L. Smith

Oct. 21, 2024

He served as associate editor of both the Journal of Biological Chemistry and the Journal of Lipid Research and was an ASBMB member for more than 40 years.