Open Letters

More thoughts on folding and form

Maurizio Brunori Arianna Brunori
By Maurizio Brunori and Arianna Brunori
Oct. 28, 2020

We were pleased to read Sudha Neelam’s pleasant and stimulating essay, “The art of paper folding and the science of protein folding,”in ASBMB Today.

Origami-bird-300x161.jpg
Daniel Álvasd/ Unsplash

Outlining the similarity between an origami and a folded protein is quite popular, since in both the form combines beauty and functional relevance. In both cases, the mechanism of folding to achieve the final state is complex. This similarity has been taken further to highlight that a misfolded origami mimics in some way a misfolded protein seen at the onset of neurodegenerative diseases that develop via irreversible population of an amyloid state by extensive misaggregation.

Folding-protein-300x315.jpg
Jawahar Swaminathan/
European Bioinformatics Institute

We should, however, recall one difference between folding a paper sheet and a polypeptide chain, a difference that is of fundamental significance.

The complex course of action to fold a paper sheet to produce origami of a chosen shape demands that precise information be injected in the procedure by an operator (in this specific case, Nihkil, the son of the writer Sudha Neelam). The order of guided steps is essential to overcome the loss of entropy coupled to the creation of an ordered object, such as a classical origami sculpture.

David-300x360.jpg
Jörg Bittner Unna/Wikimedia Commons

In the case of folding a complex 3D structurestarting from one disordered polypeptide, the information guiding the series of events/chemical steps leading to the globular protein is imprinted within the amino acid sequence. The primary structure itself is also the code carrying the instructions on how to fold in water and thereby the information to overcome the huge, unfavorable entropy loss.

In water, the amino acid sequence of a protein conforms beautifully to Aristotle’s definition of substance, the intimate ensemble of matter and form (in Greek: “synolon”), insofar as the amino acid sequence contains in itself the reason for becoming what it is (in Latin: “substantia causa sui”). In this respect, we can compare the amino acid sequence to the marble block as seen by Michelangelo Buonarroti. In Michelangelo’s view, the artist need only bring into actuality the form that already lies in the marble block by chiseling away the superfluous material.

Likewise, as shown by Nobel laureate Christian Anfinsen, the amino acid sequence embeds from the beginning the properties that will characterize the protein in the final functionally competent native state, needing only water to pass from potentiality into actuality.

 

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition weekly.

Learn more
Maurizio Brunori
Maurizio Brunori

Maurizio Brunori is emeritus president of the National Academy of the Lincei and professor emeritus at the Sapienza University of Rome.

Arianna Brunori
Arianna Brunori

Arianna Brunori is a Ph.D. student in medieval philosophy at the Scuola Normale Superiore di Pisa.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Opinions

Opinions highlights or most popular articles

Who decides when a grad student graduates?
Training

Who decides when a grad student graduates?

Nov. 15, 2024

Ph.D. programs often don’t have a set timeline. Students continue with their research until their thesis is done, which is where variability comes into play.

Redefining ‘what’s possible’ at the annual meeting
President's Message

Redefining ‘what’s possible’ at the annual meeting

Nov. 1, 2024

The ASBMB Annual Meeting is “a high-impact event — a worthwhile investment for all who are dedicated to advancing the field of biochemistry and molecular biology and their careers.”

Molecular impressions of water as cuneiform cascade*
Essay

Molecular impressions of water as cuneiform cascade*

Oct. 31, 2024

Inspired by "the most elegant depiction of H2O’s colligative features," Thomas Gorrell created a seven-tiered visual cascade of Sumerian characters beginning with the ancient sign for water.

Water rescues the enzyme
Essay

Water rescues the enzyme

Oct. 31, 2024

“Sometimes you must bend the rules to get what you want.” In the case of using water in the purification of calpain-2, it was worth the risk.

‘We’re thankful for our reviewers’
Journal News

‘We’re thankful for our reviewers’

Oct. 31, 2024

Meet some of the scientists who review manuscripts for the Journal of Biological Chemistry, Journal of Lipid Research and Molecular & Cellular Proteomics.

Water takes center stage
Essay

Water takes center stage

Oct. 24, 2024

Danielle Guarracino remembers the role water played at two moments in her life, one doing scary experiments and one facing a health scare.