Oncogenic hubs: Chromatin regulatory and transcriptional complexes in cancer
Perturbed chromatin and gene regulatory complexes are frequent determinants of aberrant gene expression in cancer and other diseases. Oncogenesis can be initiated or maintained by altered biomolecular condensates, or "hubs," involving proteins such as transcription factors, RNA-binding proteins, chromatin regulatory and ATP-dependent chromatin remodeling complexes, among others. Studies have begun to increasingly reveal the involvement of intrinsically disordered regions and phase separation potential within condensate-associated proteins in the context of cancer. Indeed, advancing our understanding of the underlying biochemical processes that govern condensate formation and function is central to the identification and development of new therapeutic opportunities targeting these mechanisms.
Organizers
Cigall Kadoch
Harvard Medical School
G. Greg Wang
Duke University School of Medicine
Symposia
Transcriptional dysregulation in cancer and diseases
- Chromatin-bound onco-condensates drive cancerous transcriptional programs
G. Greg Wang, Duke University - Decoding and targeting chromatin-associated condensates in cancer
Liling Wan, University of Pennsylvania - Specificity of condensate composition regulates transcription and is dysregulated in cancer
- Benjamin Sabari, University of Texas Southwestern Medical Center at Dallas
- Dark proteome-mediated transcriptional control in cancer at single-molecule resolution
Shasha Chong, California Institute of Technology
Histone modifications: mechanisms and therapeutic targeting
- “Oncohistones” in driving tumors and therapeutic resistance
Nada Jabado, McGill University - Biology and therapeutic targeting of cohesin-mutant myeloid malignancies
Zuzana Tothova, Dana–Farber Cancer Institute - A gateway to controlling extrachromosmal DNA amplification and rearrangements
Johnathan Whetstine, Fox Chase Cancer Center - Non-canonical functions of MLL1 in cancer
Yali Dou, University of Southern California
Mechanisms of chromatin regulatory and remodeling complexes in diseases
- Structure and function of mammalian SWI/SNF chromatin remodeling complexes in health and disease
Cigall Kadoch, Harvard Medical School; Howard Hughes Medical Institute - The role of NSD2 in epigenetic dysfunction in lymphoid malignancy
Jonathan D. Licht, University of Florida - Chromatin dynamics in cancer
Emily Bernstein, Mount Sinai School of Medicine - Dynamics of 3D genome structure and function
Anders Sejr Hansen, Massachusetts Institute of Technology
Other sessions
These sessions and activities will also be of interest. See the full program schedule for details on these and the rest of the ASBMB Annual Meeting.
Featured speakers
- Persistence and serendipity in science: a poker analogy
Melissa J. Moore, University of Massachusetts Chan Medical School - Novel GABA aminotransferase and ornithine aminotransferase inactivators as potential new treatments for epilepsy, pain and hepatocellular carcinoma
Richard Silverman, Northwestern University - Maintaining genome stability
Andre Nussenzweig, National Cancer Institute - Phase separation in cells: Insights from biophysical computations
Rohit V. Pappu, Washington University in St. Louis
Meetups
- Cancer biology
- DNA structure and function
- Epigenetics and gene regulation
- Industry scientists and industry interest
Interest group sessions
- Protein design, expression and production for drug discovery: Industry perspectives
- Recent advances in chromatin biology and transcription
Workshops
- Advocacy town hall
- Translating your functional studies for disease variant classification
- Ways to get involved in cancer prevention research with support from the National Cancer Institute
Poster sessions
- Cancer biology
- Epigenetics and gene regulation
- Omics
Events
- ASBMB welcome address
- Career and education fair
- Emerging investigator seminar
- Undergraduate poster competition
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