Metals of life: From microbes to medicine
Transition metals play important roles as cofactors and signaling molecules. Despite their essentiality, they can also be toxic. Thus, cells and organisms are challenged to sense and maintain the appropriate concentration and availability of metals and rapidly mobilize them for metalloprotein utilization and signaling. This theme will highlight the latest research findings in transition metal sensing, transport, trafficking and signaling, from microbes to humans, in both health and disease.
Organizers
Sabeeha Merchant
University of California, Berkeley
Amit Reddi
Georgia Tech
Symposia
Transition metal sensing and transport
- Extracellular heme utilization and its role in Pseudomonas aeruginosa virulence and pathogenesis
Angela Wilks, University of Maryland School of Pharmacy - Mechanisms underlying copper homeostasis in Chlamydomonas
Sabeeha Merchant, University of California, Berkeley - Multitasking functions of the IRT1 plant metal transporter
Gregory Vert, Université Paris–Saclay - Substrate selectivity in Nramp-family metal ion transporters
Rachelle Gaudet, Harvard University
Transition metal signaling
- Transitional metal signaling from metalloallostery to metalloplasia: bioinorganic chemistry beyond active sites
Christopher Chang, Princeton University - Illuminating extracellular metal dynamics: From tool development to discovery
Marie Heffern, University of California, Davis - The sensing of ferrous iron via a bacterial two-component system
Aaron Smith, University of Maryland, Baltimore - Structural and functional diversification across the heme-binding split-barrel family
Crysten Blaby–Haas, Lawrence Berkeley National Laboratory
Metal trafficking
- Illuminating heme trafficking and signaling in health and disease
Amit Reddi, Georgia Institute of Technology - Repurposing elesclomol for genetic disorders of copper deficiency
Vishal Gohil, Texas A&M University - Cracking the CIA code — understanding the molecular basis of Fe-S protein maturation by the cytosolic iron sulfur cluster assembly system
Deborah Perlstein, Boston University - Control of essential metal availability in plant cells
Sebastien Thomine, Université Paris–Saclay
Other sessions
These sessions and activities will also be of interest. See the full program schedule for details on these and the rest of the ASBMB Annual Meeting.
Featured speakers
- Persistence and serendipity in science: a poker analogy
Melissa J. Moore, University of Massachusetts Chan Medical School - Novel GABA aminotransferase and ornithine aminotransferase inactivators as potential new treatments for epilepsy, pain and hepatocellular carcinoma
Richard Silverman, Northwestern University - Molecular insights into antimalarial drug resistance
David A. Fidock, Columbia University
Meetups
- Immunology
- Industry scientists and industry interest
- Microbiology
- Plant biology and natural products
Interest group sessions
Workshops
Poster sessions
- Immunology
- Plant biology and natural products
- Microbiology
Events
- ASBMB welcome address
- Career and education fair
- Emerging investigator seminar
- Undergraduate poster competition
Make more possible
There's a whole lot more to the meeting beyond your symposium theme.
Explore the program schedule
