Interorganellar signaling and communication
Organelle crosstalk is essential for coordinating compartment-specific metabolism within the cell. Essential processes — such as redox homeostasis, bioenergetics, lipid metabolism and iron homeostasis — must be carefully orchestrated across organelles to ensure cell and organismal survival. Organelles utilize metabolites, calcium, ROS, lipids and proteins as mechanisms for crosstalk. In this theme, we delve into how organelles communicate during health and how they signal in times of stress. Communication breakdown among organelles could lead to onset of common diseases. Join us as we explore this intricate dialogue within the cell.
Organizers
Navdeep Chandel,
Northwestern University
Isha Jain
Gladstone Institutes–UCSF
Symposia
Redox
- Identification of druggable and redox vulnerabilites in cancer
Liron Bar–Peled, Massachusetts General Hospital - Mitochondria as signaling hubs that regulate stem cell function
Mireille Khacho, University of Ottawa - Principles of mitochondria as signaling organelles
Navdeep Chandel, Northwestern University - Regulation of mitochondrial health during tissue regeneration
Prashant Mishra, University of Texas Southwestern Medical Center
Stress responses
- Engineering precise mtDNA deletions by reconstituting end-joining in human mitochondria
Agnel Sfeir, Memorial Sloan Kettering Cancer Center - Genetic dissection of mitochondrial stress
Lucas Jae, Ludwig Maximilian University of Munich - Turning the oxygen and vitamin dials
Isha Jain, Gladstone Institutes - Evoking the sense of smell to coordinate homeostatic stress responses
Andrew Dillin, University of California, Berkeley
Metabolites
- TBD
Pekka Katajisto, University of Helsinki/Karolinska Institute - Metabolic regulation of tissue stem cells
Heather Christofk, University of California, Los Angeles - Tracing amino acid, acetyl-CoA, and lipid metabolic networks across organelles and tissues in health and disease
Christian Metallo, Salk Institute for Biological Studies - TBD
Tara Teslaa, University of California, Los Angeles
Other sessions
These sessions and activities will also be of interest. See the full program schedule for details on these and the rest of the ASBMB Annual Meeting.
Featured speakers
- Persistence and serendipity in science: a poker analogy
Melissa J. Moore, University of Massachusetts Chan Medical School - Novel GABA aminotransferase and ornithine aminotransferase inactivators as potential new treatments for epilepsy, pain and hepatocellular carcinoma
Richard Silverman, Northwestern University - Cell signaling by receptor tyrosine kinases: From basic principles to cancer and other therapies
Joseph Schlessinger, Yale University School of Medicine - Expanding the kinome
Vincent Tagliabracci, University of Texas Southwestern Medical Center
Meetups
- Cell and developmental Biology
- Glycobiology and extracellular matrices
- Industry scientists and industry interest
- Neurobiology
- Proteomics and mass spec
- Signal transduction
Interest group sessions
- Glycobiology for women's health
- Cell–environment interactions in health and disease
- Immune therapeutics for health and disease
Workshops
Poster sessions
- Cell and developmental Biology
- Glycobiology and extracellular matrices
- Neurobiology
- Omics
- Signal transduction
Events
- ASBMB welcome address
- Career and education fair
- Emerging investigator seminar
- Undergraduate poster competition
Make more possible
There's a whole lot more to the meeting beyond your symposium theme.
Explore the program schedule
