New frontiers in enzyme and pseudoenzyme research
Enzymes regulate and accelerate chemical reactions, ensuring that biological and biochemical processes are accomplished. Evolutionary and genomic studies revealed that many of these enzymes (pseudoenzymes) lack critical active site residues, yet maintain the three-dimensional fold. Pseudoenzymes are widespread in nature and play important roles in human health and disease. Moreover, some proteins within a superfamily act as moonlighting enzymes, which perform the canonical enzymatic function of the superfamily but also have at least one other alternate function. This theme will explore the expanding roles of these enzymes and pseudoenzymes across diverse areas of biology.
Organizers
Shantá D. Hinton
College of William and Mary
Vincent Tagliabracci
University of Texas Southwestern Medical Center
Symposium
New frontiers in enzyme and pseudoenzyme research
- Protein tyrosine phosphatases and the regulation of cell signaling: from basic research to new therapeutics
Nicholas K. Tonks, Cold Spring Harbor Laboratory - Protein AMPylation as a novel signaling mechanism in mitochondria
Anju Sreelatha, University of Texas Southwestern Medical Center - Pseudophosphatase MK-STYX: regulator of stress and neuronal signaling
Shantá D. Hinton, College of William and Mary - Death at a funeral: how activation of the zombie enzyme, MLKL, kills cells by necroptosis and leads to disease
James Murphy, Walter and Eliza Hall Institute of Medicine Research
Enzymes and pseudoenzymes in health and diseases
- Cholesterol-mediated regulation of protein tyrosine phosphatase 1B
Benoit Boivin, University at Albany - MKP-2 in sexual dimorphism and development of diabetes
Ahmed Lawan, University of Alabama in Huntsville - Cardiomyocyte-specific deletion of PTP1B protects against high-fat diet induced cardiac dysfunction
Maria Kontaridis, Masonic Medical Research Institute - Tyrosine kinase-dependent networks in Brain Metastasis reveal actionable therapeutic targets
Ann Marie Pendergast, Duke University
Structural insights in enzymes and pseudoenzymes
- Visualizing PI3K activation at the membrane with cryo-EM
Klimnet Verba, University of California, San Francisco - New insights into Ras GTPase Activating Proteins
Titus Boggon, Yale University - Enzymes, pseudoenzymes, and moonlighting proteins: diversity of functions in protein families
Constance J. Jeffrey, University of Illinois Chicago - Activation mechanisms of Receptor Tyrosine Kinases and their signaling complexes
Natalia Jura, University of California, San Francisco
Other sessions
These sessions and activities will also be of interest. See the full program schedule for details on these and the rest of the ASBMB Annual Meeting.
Featured speakers
- Persistence and serendipity in science: a poker analogy
Melissa J. Moore, University of Massachusetts Chan Medical School - Novel GABA aminotransferase and ornithine aminotransferase inactivators as potential new treatments for epilepsy, pain and hepatocellular carcinoma
Richard Silverman, Northwestern University - Expanding the kinome
Vincent Tagliabracci, University of Texas Southwestern Medical Center
Meetups
- Enzyme chemistry and catalysis
- Industry scientists and industry interest
- Proteins
Interest group sessions
Workshops
- Advocacy town hall
- Four interpretable machine learning techniques to immediately accelerate your biological research
- Use of virtual reality for biomolecular visualization in 3D
Poster sessions
- Enzyme chemistry and catalysis
- Proteins
Events
- ASBMB welcome address
- Career and education fair
- Emerging investigator seminar
- Undergraduate poster competition
Make more possible
There's a whole lot more to the meeting beyond your symposium theme.
Explore the program schedule
