Feb. 24–26, 2021 | Virtual

Proteinases and their inhibitors

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38th Winter School on proteinases and their inhibitors
Feb. 24–26, 2021

The Winter School provides a forum primarily to young scientists (pre- or post-doc) allowing them to present their exciting and/or intriguing results for discussion with leading experts. Due to the COVID-19 pandemic, this year's program will be offered virtually, hosted by the ASBMB.

Founded by Hans Fritz and Vito Turk more than three decades ago, the Winter School has been providing a scientifically stimulating and outstanding open atmosphere to researchers on proteolytic enzymes. We are excited to be holding this valuable program virtually, making it accessible to scientists around the world.

The meeting covers diverse and vibrant fields of protease research, such as mechanistic studies on proteases in their molecular, cellular and organismic context. Sessions include SARS-CoV-2, Bloody Matrix, Find your Balance & Homeostasis, Neurodegeneration & Cancer I, Cancer II, and Virus & Methods. Early career and established scientists will benefit from attending this event.

The Henner-Graeff Foundation will support this year’s Winter School by sponsoring three Young Investigator Awards with €750 each. The YIAs will recognize the best poster presentation of the Wednesday session and Thursday session as well as the best plenary talk. The participants of the meeting will select the YIA candidates by an online voting system, from which the YIA’s will be identified by the famous Winter School Committee.

The online sessions will take place between 9 a.m. – 3:30 p.m. EST | 3–9:30 p.m. CET each day.

Important dates

Feb. 22, 2021	Regular registration deadline

Organizers

Hans Brandstetter
University of Salzburg

Klaudia Brix
Jacobs University Bremen

Thomas Reinheckel
University of Freiburg

Christian Sommerhoff
University of Munich

Boris Turk
Institute Jozef Stefan, Ljubljana

Abstracts

Programming notifications

Abstract programming notifications will be sent by email on Jan. 22.
Programming notification will include date, time and format of presentation (talk or virtual poster).

All presenters must register by Feb. 1, 2021.

Registration

Registered participants will receive a link to access the virtual platform three days prior to the event date.

Not a member? Join the ASBMB and save!

Registration type	Early registration (on/before Feb. 1)		Full-price registration (Feb. 2–22)
Registration type	Members	Nonmembers	Members	Nonmembers
Regular	$100	$125	$125	$150
Industry	$100	$125	$125	$150
Early career	$50	$75	$75	$100
Graduate/Undergraduate student	$25	$50	$50	$75
Affiliate	$25	$50	$50	$75

Program schedule

Wednesday February 24

Thursday February 25

Friday February 26

Wednesday agenda

9:00 AM - 10:30 AM

SARS-CoV-2

Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 main protease using X-rays, neutrons and computation

Daniel Kneller, Oak Ridge National Laboratory

Inhibition of SARS-CoV-2 using repurposed drugs identified from in-cell protease assay and the structural characterization of protease-inhibitor complex

Jose Joyce, Pennsylvania State University

Inhibition of Furin impairs SARS-CoV-2 Spike-glycoprotein processing and reduces viral infectivity: implication of other proteases

Nabil Seidah, Montreal Clinical Research Institute

An investigation on the proteolysis of ACE2 receptor and its involvement in the cellular uptake and transmission of SARS-CoV-2

James Harte, University College Cork

Altered levels of circulating proteases are associated with peripheral blood neutrophil activation in patients with severe COVID-19

Seppe Cambier, KU Leuven

10:30 AM - 11:00 AM

Discussion and break

11:00 AM - 12:30 PM

Bloody matrix

Sulfotyrosine-mediated recognition of human thrombin by a Tsetse fly anticoagulant mimics physiological substrates

Jorge Ripoll-Rozada, Universidade do Porto

N-terminomics identification of HtrA1 substrates in cartilage

Sumit Bhutada, Cleveland Clinic Lerner Research Institute

Wound exudate degradomics in normal and impaired healing

Konstantinos Kalogeropoulos, Technical University of Denmark

Development of an inhaled cathepsin S inhibitor for the treatment of cystic fibrosis

Christine Fleming, Queens University Belfast

Functional modification of matrix metalloproteinase 9 by substrate glycosylation

Timothy Mead, Cleveland Clinic Lerner Research Institute

12:30 PM - 1:30 PM

Break

1:30 PM - 2:30 PM

Poster discussion session

2:30 PM - 3:30 PM

Social hour: Good morning Asia and Australia

Thursday agenda

9:00 AM - 10:30 AM

Find your balance & Homeostasis

Role of the membrane-bound serine proteases CAP1/Prss8 (prostasin) and CAP3/St14 (matriptase) in kidney function

Elodie Ehret, University of Lausanne

The protease cathepsin K and amino acid transporter Mct10/Tat1 are important to keep the TSH receptor in canonical basolateral localization of murine thyrocytes without affecting thyroid physiology

Vaishnavi Venugopalan, Jacobs University Bremen

Identification and characterization of legumain inhibitory cystatins from Arabidopsis thaliana

Naiá Santos, Paris Lodron University of Salzburg

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11

Betsaida Bibo Verdugo, Sanford Burnham Prebys Medical Discovery Institute

Regulated cell death is accompanied by metacaspase-like proteolysis in unicellular eukaryotes

Katarina van Midden, University of Ljubljana

10:30 AM - 11:00 AM

Discussion and break

11:00 AM - 12:30 PM

Neurodegeneration & Cancer I

Understanding PARL-dependent cleavage of PINK1 in mitochondrial health and Parkinson's disease

Raelynn Brassard, University of Alberta

The role of Presenilin (PS)/γ-secretase in selective neuronal vulnerability

Masato Maesako, Massachusetts General Hospital/Harvard Medical School

An infection-activated redox switch in the lysosomal protease legumain promotes tumor growth

Yekaterina Kovalyova, Yale University

Dispatched-activated Sonic Hedgehog shedding via regulation of the membrane cholesterol content

Kristina Ehring, University of Münster

Cancer cell derived ADAM17 mediates education of pro-tumorigenic macrophages via a HB-EGF-CXCL1 feedback loop

Sebastian Gnosa, University of Copenhagen

12:30 PM - 1:30 PM

Break

1:30 PM - 2:30 PM

Poster discussion session

2:30 PM - 3:30 PM

Social hour: Good morning Asia and Australia

2:30 PM - 3:30 PM

Career-development session

The theme of this session is “How to manage an academic career during interesting times.” This relates not only to the pandemic impacting lab work and job searches but also to managing family life while swinging pipettes and writing papers and grant applications. We also will discuss how to become (and stay) a group leader in either industry or academia. All are invited to participate.

Friday agenda

9:00 AM - 10:30 AM

Cancer II

Dipeptidyl peptidases 8 and 9 have differential functions in Luminal-A and Triple-negative breast cancer cells

Aaron Bettecken, Albert-Ludwigs-University Freiburg

DPP9 promotes DNA-damage repair by targeting BRCA2 to the N-degron pathway

Oguz Bolgi, University of Freiburg

Protease networks in the subtype-specific tumour-stroma crosstalk in pancreatic cancer

Foram Vyas, University of Toronto

Extracellular vesicle based communication in the tumour microenvironment of pancreatic ductal adenocarcinoma: a specific role for ADAM8

Lena Cook, University Hospital Marburg

Validation of MMP-7 as a target for inhibition of pancreatic tumor cell invasion by compounds that bind a novel remote allosteric site

Steven Van Dooren, University of Copenhagen

10:30 AM - 11:00 AM

Discussion and break

11:00 AM - 12:30 PM

Virus & Methods

More than one mechanism involved in HIV-1 protease inhibitor resistance

Ryan Jeep, Colorado State University

SAR-driving interactions between cruzain of Trypanosoma cruzi and natural product gallinamide A assist in designing of gallinamide analogs as potent inhibitors of T. cruzi

Elany Barbosa da Silva, Skaggs School of Pharmacy and Pharmaceutical Sciences

Molecular insights into secreted serine protease toxins from Escherichia coli pathogens reveal approaches to combat diarrheal infections

Akila Pilapitiya, La Trobe University

From ELISA to immunosorbent tandem mass spectrometry proteoform analysis (ISTAMPA): the example of CXCL8/interleukin-8

Mieke Metzemaekers, KU Leuven

Human Legumain — a novel tool for proteomics

Maithreyan Kuppusamy, Central Institute for Engineering, Electronics and Analytics

12:30 PM - 1:30 PM

Break

1:30 PM - 3:00 PM

Award ceremony

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