Mechanistic Impacts of Post-translation Modifications

Theme organizers:

          Philip Cole  Paul Thompson
Philip Cole
Johns Hopkins School
Of Medicine

Paul R. Thompson
University of Massachusetts
Medical School 

 Posttranslational Modifications of Lysine

Sunday, March 29, 2015, 3:55 PM - 6:10 PM • Room 258A

Follow the conversation: #PTMs

Chaired: P. R. Thompson  

3:55                        Chair’s Introduction.

4:00      107.1       A Chemical Toolbox for Lysine Deacetylases D. Schwarzer. Univ. of Tübingen.

4:25                        Mechanism of Nicotinamide Riboside as an Aid to Weight Loss C. Brenner, B.J. Weidemann, S.A.J. Trammell, J.J. Coon, L. Yu, M.E. Migaud and J.L. Grobe. Univ. of Iowa, Queens Univ. Belfast and Univ. of Wisconsin-Madison. (717.19)

4:40      107.2       Protein Methyltransferase Inhibitors as Cancer Therapeutics R.A. Copeland. Epizyme Inc., Cambridge, MA.

5:05                        N-Chlorination, a Reversible Post-translational Modification that Activates Chaperone Function in RidA A. Müller, S. Langklotz, N. Lupilova, K. Kuhlmann, J.E. Bandow and L.I.O. Leichert. Ruhr Univ. Bochum. (717.3)

5:20                        Evaluating the Role of Histone H2A Variants and Epigenetic Modification in the DNA Repair System of Bdelloid Rotifers M.A. McFadden, J.S. Higgins and A.M. Schurko. Hendrix Col., AK. (877.22)

5:35      107.3       Targeting Reversible Lysine Modifications P. Cole. Johns Hopkins Univ. Sch. of Med.

6:00                        Discussion.

Posttranslational Modifications of Arginine:  Methylation, Citrullination, Phosphorylation

Monday, March 30, 2015, 9:45 AM - 12:00 PM • Room 258A

Chaired: P. Cole

9:45                        Chair’s Introduction.

9:50      224.1       Picking the PADlock: Chemical Probes to Study the Protein Arginine Deiminases P.R. Thompson. UMass Med. Sch.

10:15                      Targeting Citrullination in the Injured Retina J.W. Wizeman, A.P. Nicholas and R. Mohan. Univ. of Connecitcut Hlth. Ctr. and Univ. of Alabama at Birmingham. (717.15)

10:30    224.2       Positive Feedback Regulation in Histone Demethylases D.G. Fujimori. UCSF.

10:55                      Redox Control of Protein Arginine Methyltransferase 1 Activity J. Hevel, Y. Morales, D.V. Nitzel, O.M. Price and S. Gui. Utah State Univ. (717.18)

11:10                      Protein Arginine Methylation of Tubulin Beta Decreases Binding of Taxol in Neuro2a Cells S.C. Piller, N.K. Jwad, L. Hejazi, R. Gamsjaeger and N.J. Sucher. Univ. of Western Sydney and Roxbury Community Col., MA. (717.16)

11:25    224.3       Structure and Function of the Protein Arginine Kinase McsB T. Clausen, D. Broch Trentini and M.J. Suskiewicz. Inst. of Molec. Pathol., Vienna.

11:50                      Discussion.

Posttranslational Modifications of Cysteine: Lipidation and Oxidation

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM • Room 258A

Chaired: G. W. Hart

3:55                        Chair’s Introduction.

4:00      370.1       A Chemical-Proteomic Platform to Investigate Cysteine S-Nitrosation E. Weerapana. Boston Col.

4:25                        Cysteinylation of the ALS-Associated Protein SOD1 Confers Resistance to Oxidation J. Auclair, D. Ringe, G. Petsko and J. Agar. Brandeis Univ. and Northeastern Univ. (717.1)

4:40      370.2       Rescuing Cell Polarity with Small Molecule Inhibitors of De-palmitoylation B. Martin. Univ. of Michigan.

5:05                        Meta-proteomic Analysis of PTMs in G Protein Signaling Systems – New Tools and Unsuspected Discoveries M. Torres, H. Dewhurst and S. Choudhury. Georgia Inst. of Technol. (728.41)

5:20                        Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response Y. Aye, S. Parvez and Y. Fu. Cornell Univ. and Weill Cornell Med. Col. (570.1)

5:35      370.3       Mechanism and Function of DHHC Palmitoyltransferases M. Linder, C. Gottlieb, M. Malgapo and W. Greentree. Cornell Univ.

6:00                        Discussion.

O-GlcNAcylatoin: How Sweet It Is

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM • Room 258A

Chaired: E. Weerapana

9:00                        Chair’s Introduction.

9:05      489.1       The Split Personality of Human O-GlcNAc Transferase S. Walker. Harvard Med. Sch.

9:30                        Defining the Mechanism of O-GlcNAc Signaling in Stress-Induced Autophagy and Cardioprotection K. Fahie, M. McCartin, M. Wolfgang and N. Zachara. Johns Hopkins Univ. Sch. of Med. (717.8)

9:45      489.2       O-GlcNAcylation of CaMKII in Cardiac Myocytes Can Be Pro-arrhythmic D. Bers. Univ. of California, Davis.

10:10                      O-GlcNAc Modified Residues of IRS1 Impact Postprandial Lipid Metabolism L.E. Ball, K. Robinson, M.N. Berkaw and M.G. Buse. Med. Univ. of South Carolina. (728.47)

10:25                      Sweet Tooth of a Glucose Transporter: GLUT1 C-Terminal Phosphorylation and O-GlcNacylation Effect in Breast Cancer Cell Lines G.P. Padilla-Meier and S. Mishra. Univ. of Manitoba. (717.14)

10:40    489.3       Nutrient Regulation of Signaling and Transcription by O-GlcNAcylation G.W. Hart. Johns Hopkins Univ. Sch. of Med.

11:05                      Discussion.