New Directions in Enzymology

Abstract deadline extended to Monday, November 10 at 5PM, EST

Theme organizers:


Kate S. Carroll
The Scripps Res. Inst.

Liz Hedstrom
Brandeis Univ.

This theme is made up of four symposia, one scheduled each day of the meeting, Sun – Wed.  Please read below for invited speaker and session schedule information.  In addition to the invited talks listed below, short talks will be selected from the submitted abstracts.  To be considered for a volunteered talk in this theme, submit your abstract to an ASBMB topic category number: 2270-2287, by the November 6th submission deadline.  All volunteered abstracts will be programmed for poster presentation.  Those selected for oral presentation will also present a poster.  Programming notifications will be sent in mid-January.  We look forward to seeing you at the Boston Convention and Exhibition Center, BCEC, March 28 – April 1, 2015.

New Reactions of Old Cofactors

Sunday, March 29, 2015, 9:45 AM - 12:00 PM
Room 258A

Session Chair: Carol Fierke, Univ. of Michigan

Invited Speakers:

Tadgh P. Begley, Texas A&M Univ.
The mechanistic enzymology of thiamin biosynthesis

Lizbeth Hedstrom, Brandeis Univ.
Cofactor dynamics in GMP reductase  

Bradley Moore, UCSD
Natural product biosynthesis - A treasure trove of multitalented flavoenzymes

Discovering New Enzymes

Monday, March 30, 2015, 3:55 PM - 6:10 PM
Room 258A 

Session Chair: Hening Lin, Cornell Univ.

Invited Speakers:

Karen N. Allen, Boston Univ.
Specificity and Promiscuity in Enzyme Superfamilies

Margaret A. Phillips, UT Southwestern Med. Ctr.
Pseudoenzymes as activators of enzyme function: the prozyme paradigm in trypanosomatid polyamine metabolism

Frank M. Raushel, Texas A&M Univ.
The Discovery of New Enzymes in the Human Gut Microbiome

Enzyme Modules and Complexes

Tuesday, March 31, 2015, 9:45 AM - 12:00 PM
Room 258A 

Session Chair: Karen N. Allen, Boston Univ.

Invited Speakers:

Francisco J. Asturias, The Scripps Res. Inst.
Quaternary structure and activity modulation in human ribonucleotide reductase

Eileen K. Jaffe, Fox Chase Cancer Ctr., Temple UHS
Quaternary structure dynamics in allostery - application to mammalian phenylalanine hydroxylase

Vicki Hopper Wysocki, The Ohio State Univ.
Mass Spectrometry in Structural Biology: Surface-induced Dissociation/Ion Mobility of Protein Complexes

Strategies for Substrate Recognition

Wednesday, April 1, 2015, 1:15 PM - 3:30 PM
Room 258A

Session Chair: Liz Hedstrom, Brandeis Univ.

Invited Speakers:
Carol Fierke, Univ. of Michigan
Ribozymes to Proteins:  Evolution of Enzymes Catalyzing tRNA Processing 

Hening Lin, Cornell Univ.
Sirtuins and novel protein posttranslational modifications

Wilfred van der Donk, Univ. of Illinois
Substrate recognition in Lanthipeptide Synthesis