Cancer: The war at 44, Warburg at 90

Theme organizer

Neal Fedarko
Johns Hopkins Univ.

Imaging: A Picture is Worth > 1,000 Words

Follow the conversation: #cancer

Sunday, March 29, 2015, 3:55 PM - 6:10 PM • Room 254A/B

Chaired: N. Fedarko

3:55        Chair’s Introduction.

4:00    104.1    Ras-Induced Macropinocytosis: Metabolic Adaptation to Signaling in the Absence of Adequate Nutrients C.B. Thompson. Mem. Sloan-Kettering Cancer Ctr.

4:25        New Strategies for Probing and Inhibiting CDK4/cyclin D Hyperactivity in Melanoma C. Prével, M. Pellerano, F. Bihel, L. Meunier and M.C. Morris. Biomolec Inst. Max Mousseron Fac. of Pharm., Montpellier and Fac. of Pharm.-UMR CNRS, Srasbourg. (577.4)

4:40    Withdrawn presentation.  Replacement tba.

5:05        Monitoring Cellular Adenine Nucleotide Levels and Their Relevance to Cellular Metabolic Functions Using Bioluminescence-Based Strategies S. Goueli, K. Hsiao and S. Mondal. Promega Corp., Madison and Univ. of Wisconsin Med. Sch. (577.6)

5:20        Imaging Tumor Targeted Delivery Using FRET In Vivo M. Barroso, A. Rudkouskaya, K. Anderson, S. Rajoria, L. Zhao, N. Sinsuebphon and X. Intes. Albany Med. Col. and Rensselaer Polytech Inst. (577.1)

5:35    104.3    PET Radiopharmaceuticals for the Diagnosis of Cancer J.S. Lewis. Mem. Sloan-Kettering Cancer Ctr.

6:00        Discussion.

RNA: Beyond Messages and Translation (Micro and Long Noncoding RNA)

Follow the conversation: #cancer

Monday, March 30, 2015, 9:45 AM - 12:00 PM • Room 254A/B

Chaired: C.D. Helgason

9:45        Chair’s Introduction.

9:50        Long Noncoding RNAs in Acute myeloid Leukemia R. Garzon. The Ohio State Univ.

10:15      A MicroRNA Signature of Response to Erlotinib Is Impacted by the EMT-Inducing Cytokine TGFβ1 M.J. Krentz, R. Astley and E.P. Black. Univ. of Kentucky. (578.3)

10:30    221.2    Role of Exosomic MicroRNAs in Cancer Cell Cross-Talk within the Tumor Microenvironment M. Fabbri, P. Wise, M. Murtadha, P. Neviani and K. Challagundla. Children’s Hosp. Los Angeles, Univ. of So. California.

10:55        PKCδVIII and Bcl2 Increase Ovarian Cancer Survival via LncRNA NEAT1 Secreted by Obese Adipose-Derived Stem Cells N.A. Patel, A. Morris, R.S. Patel, G. Carter, D.R. Cooper and M. Murr. James A Haley Veterans Hosp., Tampa and Univ. of South Florida. (578.7)

11:10        Cancer Cell-Induced Suppression of Cytotoxic Alu RNA Biosynthesis in the Co-cultured Macrophages A. Singhal, S. Mishra and G. Chaudhuri. Meharry Med. Col. (578.10)

11:25    221.3    The Non-coding Transcriptome as a Dynamic Regulator of Prostate Cancer Metastasis C.D. Helgason, A. Parolia, R. Liu, H. Xu, Y. Wang and F. Crea. British Columbia Cancer Agcy. Res. Ctr. and Vancouver Gen. Hosp.

11:50    Discussion.

Metabolism: Warburg at 90

Follow the conversation: #cancer

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM • Room 254A/B

Chaired: E. A. Maher

3:55        Chair’s Introduction.

4:00    367.1    Metabolism, Metabolomics and Cancer D.L. Wishart. Univ. of Alberta.

4:25        Targeting 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-4 in Cancer S. Telang, J. Trent, J. Chesney and J. Clark. Univ. of Louisville. (725.29)

4:40    367.2    Using Comparative Metabolomics to Target Cancer J.L. Griffin. Univ. of Cambridge and MRC Human Nutr. Res.

5:05        GTP Metabolism Regulates Cancer Cell Invasion M.A. Nikiforov and A. Bianchi-Smiraglia. Roswell Park Cancer Inst. (725.12)

5:35    367.3    Metabolic Complexity of Aggressive Primary and Metastatic Brain Tumors beyond the Warburg Effect: What Substrates Are Fueling the Citric Acid Cycle? E.A. Maher. Univ. of Texas Southwestern Med. Ctr.

6:00        Discussion.

Biologics: Antibodies and Antidotes

Follow the conversation: #cancer

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM • Room 254A/B

Chaired: Tba

9:00        Chair’s Introduction.

9:05    486.1    Update on the Development of Curative Cancer Immunotherapies N.P. Restifo. NCI, NIH.

9:30        Antibody Directed Enzyme Prodrug Therapy: Discovery of Novel Genes, Isolation of Novel Gene Variants and Production of Long Acting Drugs for Efficient Cancer Treatment S.K. Goda. Anti-doping Lab., Doha, Qatar. (897.28)

9:45    486.2    GPCR-Targetng Nanobodes as Attractive Research Tools, Diagnostics and Therapeutics M.J. Smit. VU Univ. Amsterdam.

10:10      Angiotensin-(1-7) as an Antinociceptive Agent in Cancer-Induced Bone Pain B.L. Forte, L.M. Slosky, W.D. Staatz, T.M. Largent-Milnes and T.W. Vanderah. Univ. of Arizona. (897.4)

10:25      Cancer Immunotherapy via Regulation of the Ubiquitin Proteasome Pathway S. Kumar, J. Wu, J. LaRocque, S. Agarwal, J. Marblestone, M. Kodrasov, J. Weinstock and M. Mattern. Progenra Inc., Malvern, PA. (897.33)

10:40    486.3    Immunomodulation Therapy Goes to Tumor Site L. Chen. Yale Sch. of Mgmt.

11:05        Discussion