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Protein Nonfolding as a Regulatory Phenomenon

Theme organizers:

Elizabeth Rhoades, Yale Univ.   Scott Showalter, The Pennsylvania State Univ.

This theme is made up of four symposia, one scheduled each day of the meeting, Sun – Wed.  Please read below for invited speaker and session schedule information.  In addition to the invited talks listed below, short talks will be selected from the submitted abstracts.  To be considered for a volunteered talk in this theme, submit your abstract to an ASBMB topic category number: 2090-2108, by the November 6th submission deadline.  All volunteered abstracts will be programmed for poster presentation.  Those selected for oral presentation will also present a poster.  Programming notifications will be sent in mid-January.  We look forward to seeing you at the Boston Convention and Exhibition Center, BCEC, March 28 – April 1, 2015.

Mediating Protein Interactions: Is Folding Required?

Sunday, March 29, 2015, 3:55 PM - 6:10 PM
Room 258C

Session Chair: Elizabeth Rhoades, Yale Univ.

Invited Speakers:

Jane Clark, Univ. of Cambridge
Mechanisms of folding upon binding

Ashok Deniz, The Scripps Res. Inst.
Allostery modulation by protein intrinsic disorder at single molecule resolution

Tanja Mittag, St. Jude Children's Res. Hosp.
The role of substrate disorder and multivalency in regulating ubiquitination

Regulating Functional Interactions by Dysfunctional Proteins

Monday, March 30, 2015, 9:45 AM - 12:00 PM
Room 258C

Session Chair: Carlos Camacho, Univ. of Pittsburgh         

Invited Speakers:

David Eliezer, Weill Cornell Med. Col.
Structural biology of tau and alpha-synuclein

Elizabeth Rhoades, Yale Univ.
Determining a functional mechanism of a dysfunctional protein

Collin Stultz, MIT
The mechanism of amyloid beta fiber elongation

Defining Protein Disorder

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM
Room 258C

Session Chair: Steve Metallo, Georgetown Univ.

Invited Speakers:

Mónika Fuxreiter, Univ. of Debrecen
Fuzziness imparts versatility on signaling

Jörg Gsponer, Univ. of  British Columbia
Promiscuous but still selective in partner selection

Scott A. Showalter, The Pennsylvania State Univ.
Assessing Intrinsically Disordered Protein Structure and Function through Carbon Detected NMR

Targeting Disorder with Small Molecules

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM
Room 258C

Session Chair: Scott Showalter, The Pennsylvania State Univ.    

Invited Speakers:

Carlos J. Camacho, Univ. of Pittsburgh
Modulating the regulatory role of disordered proteins using small molecules

Steven J. Metallo, Georgetown Univ.
Specificity and Promiscuity in Small Molecule Binding to Intrinsically Disordered Protein Regions

Sheena E. Radford, Univ. of Leeds
Biophysical studies of amyloid formation mechanisms